Guidelines for thrombolytic therapy for acute stroke a supplement to the guidelines for the management of patients with acute ischemic stroke was approved by the american heart association science advisory and coordinating committee on june 20 1996 harold p adams. Alteplase thrombolysis for acute noninterventional therapy in ischemic stroke jama 1999 dec282212019 2026 pmid 10591384 the rtpa alteplase 0 to 6 hour acute stroke trial part a a0276g results of a double blind placebo controlled multicenter study thrombolytic therapy in acute ischemic stroke study investigators. An 81 year old man presents to the er with an acute ischemic stroke iv thrombolytic therapy is recommended administered as a therapeutic agent within 45 hours after stroke tissue plasminogen . The enormous success of treating coronary thrombosis with thrombolytic therapy makes the treatment of ischaemic stroke the obvious next step several large trials have confirmed the benefits of thrombolysis in acute stroke within three hours of development of symptoms eg national institute of neurological disorders and stroke ninds in the usa. Background ischemic cerebrovascular accidents remain a leading cause of morbidity and mortality thrombolytic therapy for acute ischemic stroke within 3 h of symptom onset of highly select patients has been advocated by some groups since 1995 but trials have yielded inconsistent outcomes
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