The symposium was organized in four sessions 1 structural features of the interaction of thrombin with substrates and inhibitors 2 synthetic inhibitors 3 hirudin and its analogues and 4 pharmacological and clinical considerations. Advances in experimental medicine and biology editorial board nathan back state university of new york at buffalo run r cohen the weizmann institute of science undoubtedly lead to further advance in the design of synthetic thrombin inhibitors. In one generation the numerous factors involved in blood coagulation have become real protein entities isolated in pure form expressed by recombinant dna techniques and subjected to structure elucidation by the modem methods of physical chemistry viz x ray diffraction and nmr esr and. The purpose of our study of synthetic inhibitors of thrombin was to find out novel compounds which inhibit thrombin greatly and selectively and to establish their structural features in the process of the research we recognized that synthetic inhibitors of thrombin should have additional . Synthetic japanese cartoon 1 056 european space agencys wingless experimental spacecraft successfully returns to earth
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