Granulomatosis with polyangiitis gpa wegeners granulomatosis and microscopic polyangiitis mpa with glucocorticoids pemphigus vulgaris pv to treat moderate to severe pv it is not known if rituxan is safe and effective in children. Rheumatoid arthritis ra in combination with methotrexate in adult patients with moderately to severely active ra who have inadequate response to one or more tnf antagonist therapies 13 granulomatosis with polyangiitis gpa wegeners granulomatosis and microscopic polyangiitis mpa in adult patients in combination with. Fda approval of rituxan for wegeners and microscopic polyangiitis april 2011 on april 19 2011 the us food and drug administration approved the drug rituxanr rituximab in combination with glucocorticosteroids for the treatment of two forms of anca associated vasculitis granulomatosis with polyangiitis wegeners and microscopic polyangiitis. Recommended dose for rheumatoid arthritis ra administer rituxan as two 1000 mg intravenous infusions separated by 2 weeks gpa wegeners granulomatosis and microscopic polyangiitis mpa begin within 14 days prior to or with the initiation of rituxan and may continue during and after the 4 week course of rituximab treatment
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