Combination treatment for hypertension is individualized it gives the best possible control of blood pressure with the fewest side effects also combination treatment may cost less. Combination therapy is treatment with two or more agents administered separately or in a fixed dose combination pill and is required by most patients with hypertension to reach target blood . Table 4 lists the low dose combinations currently available for the treatment of hypertension the concept of low dose combination therapy was derived primarily from the experience with diuretics. Combination therapy may be theoretically favored by the fact that multiple factors contribute to hypertension and achieving control of blood pressure with single agent acting through one particular mechanism may not be possible regimens can either be fixed dose combinations or drugs added sequentially one after other. Evidence suggests that combination therapy particularly with a calcium channel blocker diuretic or ace inhibitor is associated with less sbp variability and therefore improved outcomes 11 the benefit of combination therapy in the treatment of hypertension is clear and is likely necessary for most patients
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