Fibrous dysplasia is a genetic disease caused by activating missense mutations of the gsa gene the disease has variable severity and often combines with extraskeletal disorders which like the bone lesions reflect the adverse effects of the mutation. Fibrous dysplasia is a disorder where normal bone and marrow is replaced with fibrous tissue resulting in formation of bone that is weak and prone to expansionas a result most complications result from fracture deformity functional impairment and pain disease occurs along a broad clinical spectrum ranging from asymptomatic incidental lesions to severe disabling disease. Fibrous dysplasia is an uncommon bone disorder in which scar like fibrous tissue develops in place of normal bone this irregular tissue can weaken the affected bone and cause it to deform or fracture in most cases fibrous dysplasia occurs at a single site in one bone but can occur at multiple sites in multiple bones. Fibrous dysplasia fd is a rare bone disorder bone affected by this disorder is replaced by abnormal scar like fibrous connective tissue pairs of human chromosomes are numbered from 1 through 22 and the sex chromosomes are designated x and y males have one x and one y chromosome and females have two x chromosomes cherubism is a
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